How is the NAB-SURE SARS CoV-2 Assay different from other antibody tests?
Other SARS CoV-2 antibody detection methods include plaque reduction tests (PRNT), ELISA and EIA immunoassays. Cell-based PRNT tests take several days and require Bio Safety Level 3 handling due to the exposure risk using a live virus. Present ELISA and EIA immunoassays detect total antibodies against either SARS-CoV-2, the S1 protein or the Receptor Binding Domain (RBD) on S1. NAB-SURE SARS CoV-2 Assay is specific to neutralizing antibodies as opposed to total antibodies. Studies show these neutralizing antibodies are correlated with reduced COVID-19 infections. In addition, existing neutralizing antibody tests for RBD do not have the sensitivity to detect antibodies in from a small sample size.