What are neutralizing antibody assays for SARS-CoV-2?

Neutralizing antibody assays specifically detect antibodies which block SARS-CoV-2 virus from entering cells and are correlated with reduced COVID-19 infections. Existing methods to detect these antibodies include the plaque reduction test which measures inhibition of SARS-CoV-2 binding to cells in cell culture, and ELISA or EIA serological assays which detect antibodies to the S1 protein or to the Receptor Binding Domain (RBD) on S1.

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