What is the Spear Bio technology?
Spear Bio uses their proprietary SPEAR (Successive Proximity Extension Amplification Reaction assay) technology. The NAB-SURE™ SARS CoV-2 assay uses selected oligonucleotides conjugated to antibodies. These oligos can only be extended when they are in proximity, such as when the antibodies have bound to the same target. Primer extended products are then detected by standard qPCR using common thermocyclers. The NAb-Sure™ SARS CoV-2 assay is an inhibition format of this technology that uses free RBD to inhibit the S1conjugate signal. The assay is accurate, and highly sensitive and compares favorably with the plaque reduction test, and existing neutralizing antibody assays.